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Protein SH3GL2 PDB 1x03.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases SH3GL2, CNSA2, EEN-B1, SH3D2A, SH3P4, SH3 domain containing GRB2 like 2, endophilin A1
External IDs MGI: 700009 HomoloGene: 20652 GeneCards: SH3GL2
Genetically Related Diseases
Parkinson's disease[1]
RNA expression pattern
PBB GE SH3GL2 205751 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 17.58 – 17.8 Mb Chr 4: 85.21 – 85.64 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.[4][5]


SH3GL2 has been shown to interact with DNM1,[6][7] Amphiphysin,[6][7] ADAM9,[8] SH3KBP1[9] and ADAM15.[8]


  1. ^ "Diseases that are genetically associated with SH3GL2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Giachino C; Lantelme E; Lanzetti L; Saccone S; Bella Valle G; Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142. 
  5. ^ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2". 
  6. ^ a b Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. UNITED STATES. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. ISSN 0021-9258. PMID 9341169. 
  7. ^ a b Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. United States. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. ISSN 0021-9258. PMID 12456676. 
  8. ^ a b Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. UNITED STATES. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. ISSN 0021-9258. PMID 10531379. 
  9. ^ Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. England. 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. 

Further reading[edit]