SH3GL3

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SH3GL3
Protein SH3GL3 PDB 2ew3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SH3GL3, CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13, SH3 domain containing GRB2 like endophilin A3, SH3 domain containing GRB2 like 3, endophilin A3
External IDs MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SH3GL3
Genomic location for SH3GL3
Band 15q25.2 Start 83,447,228 bp[1]
End 83,618,743 bp[1]
RNA expression pattern
PBB GE SH3GL3 gnf1h02192 x at fs.png

PBB GE SH3GL3 205637 s at fs.png

PBB GE SH3GL3 gnf1h02191 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277954
NM_001277955
NM_017400

RefSeq (protein)

NP_001264883
NP_001264884
NP_059096

Location (UCSC) Chr 15: 83.45 – 83.62 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.[4][5]

Interactions[edit]

SH3GL3 has been shown to interact with Huntingtin[6] and SH3KBP1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140600 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142. 
  5. ^ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3". 
  6. ^ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064. 
  7. ^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096. 

Further reading[edit]