SH3RF1

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SH3RF1
Identifiers
Aliases SH3RF1, POSH, RNF142, SH3MD2, SH3 domain containing ring finger 1
External IDs MGI: 1913066 HomoloGene: 10988 GeneCards: SH3RF1
RNA expression pattern
PBB GE SH3RF1 gnf1h05668 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020870

NM_021506
NM_198678

RefSeq (protein)

NP_065921

NP_067481.2
NP_067481

Location (UCSC) Chr 4: 169.09 – 169.27 Mb Chr 8: 61.22 – 61.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[3][4]

Function[edit]

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[4]

Interactions[edit]

SH3RF1 has been shown to interact with AKT2[5] and MAP3K11.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487Freely accessible. PMID 9482736. 
  4. ^ a b "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1". 
  5. ^ a b Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284. 

Further reading[edit]