SHC014-CoV is a SARS-like coronavirus (SL-COV) which infects horseshoe bats (family Rhinolophidae). It was discovered in Kunming County in Yunnan Province, China. It was discovered along with SL-CoV Rs3367, which was the first bat SARS-like coronavirus shown to directly infect a human cell line. The line of Rs3367 that infected human cells was named Bat SARS-like coronavirus WIV1.
From April 2011 to September 2012, researchers from the Wuhan Institute of Viriology collected 117 anal swabs and fecal samples of bats from a Chinese rufous horseshoe bats (Rhinolophus sinicus) colony in Kunming City (Yunnan Province in south-western China). Twenty-seven out of 117 samples (23%) contained seven different isolates of SARS-like coronaviruses, among which were two previously unknown, called RsSHC014 and Rs3367.
In 2013, bat SARS-like coronavirus Rs3367 was shown to be able to directly infect the human HeLa cell line. It was the first time that human cells had been infected with a bat SARS-like coronavirus in the lab. The strain of Rs3367 that infected the human cells was named Bat SARS-like coronavirus WIV1.
In 2015, the University of North Carolina at Chapel Hill and the Wuhan Institute of Virology conducted research showing that SHC014 could be made to infect the human HeLa cell line, through the use of reverse genetics to create a chimeric virus consisting of a surface protein of SHC014 and the backbone of a SARS virus.
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