SHC3

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SHC3
Identifiers
AliasesSHC3, N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3
External IDsMGI: 106179 HomoloGene: 7536 GeneCards: SHC3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SHC3
Genomic location for SHC3
Band9q22.1Start89,005,771 bp[1]
End89,178,767 bp[1]
RNA expression pattern
PBB GE SHC3 206330 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016848

NM_009167

RefSeq (protein)

NP_058544

NP_033193

Location (UCSC)Chr 9: 89.01 – 89.18 MbChr 13: 51.43 – 51.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.[5][6]


Interactions[edit]

SHC3 has been shown to interact with RICS[7] and TrkB.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148082 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021448 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
  6. ^ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
  7. ^ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. United States. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789.
  8. ^ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002.
  9. ^ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. United States. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588.

Further reading[edit]