SIB-1553A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SIB-1553A
SIB-1553A.svg
Names
IUPAC name
(R/S)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride
Identifiers
191611-76-4 YesY
ChEMBL ChEMBL47850
ChemSpider 4470512
Jmol 3D model Interactive image
PubChem 5310968
Properties
C13H19NOS
Molar mass 237.36 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β4 subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model.[1]

References[edit]

  1. ^ Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics. 306 (1): 401–6. doi:10.1124/jpet.103.051912. PMID 12721323.