SIBLING proteins

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The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. Evidence shows that these proteins play key roles in the mineralization of these tissues.[1]

The following are categorized as SIBLING proteins:[1][2]

  1. osteopontin (OPN)
  2. bone sialoprotein (BSP)
  3. dentin matrix protein 1 (DMP1)
  4. dentin sialophosphoprotein (DSPP)
  5. matrix extracellular phosphoglycoprotein (MEPE)

The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.[3]


  1. ^ a b Qin, C.; Baba, O.; Butler, W.T. (2004). "Post-Translational Modifications of Sibling Proteins and Their Roles in Osteogenesis and Dentinogenesis". Critical Reviews in Oral Biology & Medicine. 15 (3): 126–36. PMID 15187031. doi:10.1177/154411130401500302. 
  2. ^ Chaplet, M; De Leval, L; Waltregny, D; Detry, C; Fornaciari, G; Bevilacqua, G; Fisher, LW; Castronovo, V; Bellahcène, A (2003). "Dentin Matrix Protein 1 is Expressed in Human Lung Cancer". Journal of Bone and Mineral Research. 18 (8): 1506–12. PMID 12929940. doi:10.1359/jbmr.2003.18.8.1506. INIST:15005341. 
  3. ^ Rittling, Susan R.; Denhardt, David T. (1999). "Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice". Nephron Experimental Nephrology. 7 (2): 103–13. PMID 10213864. doi:10.1159/000020591.