The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. Evidence shows that these proteins play key roles in the mineralization of these tissues.
- osteopontin (OPN)
- bone sialoprotein (BSP)
- dentin matrix protein 1 (DMP1)
- dentin sialophosphoprotein (DSPP)
- matrix extracellular phosphoglycoprotein (MEPE)
The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.
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