SIGIRR

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SIGIRR
Identifiers
Aliases SIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDs MGI: 1344402 HomoloGene: 36399 GeneCards: SIGIRR
RNA expression pattern
PBB GE SIGIRR 52940 at fs.png

PBB GE SIGIRR 218921 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135053
NM_001135054
NM_021805

NM_023059

RefSeq (protein)

NP_001128525
NP_001128526
NP_068577

NP_075546.2
NP_075546

Location (UCSC) Chr 11: 0.41 – 0.42 Mb Chr 7: 141.09 – 141.1 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.[3][4]

It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.[5][6]

Interactions[edit]

SIGIRR has been shown to interact with TRAF6.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Thomassen E, Renshaw BR, Sims JE (Jul 1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978. 
  4. ^ "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain". 
  5. ^ a b Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853. 
  6. ^ Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (April 2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity. 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123. 

Further reading[edit]