SIGLEC10

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SIGLEC10
Identifiers
AliasesSIGLEC10, PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10
External IDsOMIM: 606091 MGI: 2443630 HomoloGene: 13228 GeneCards: SIGLEC10
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SIGLEC10
Genomic location for SIGLEC10
Band19q13.41Start51,410,020 bp[1]
End51,417,803 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_172900

RefSeq (protein)

NP_766488

Location (UCSC)Chr 19: 51.41 – 51.42 MbChr 7: 43.41 – 43.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10 [7]

Structure and Function[edit]

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.[8] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene Family summary[edit]

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142512 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030468 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.
  6. ^ a b "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
  7. ^ Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H (Nov 2018). "Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells". J. Clin. Invest. 128 (Pt 11): 4912–23. doi:10.1172/JCI120612. PMC 6205408. PMID 30130255.
  8. ^ Clark, M. & A. Cooke (2013). "Regulation unmasked by activation". Nat Immunol. 14 (7): 696–697. doi:10.1038/ni.2646. PMID 23778805.

Further reading[edit]