SIPA1

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SIPA1
Identifiers
Aliases SIPA1, SPA1, signal-induced proliferation-associated 1
External IDs MGI: 107576 HomoloGene: 7940 GeneCards: SIPA1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006747
NM_153253

NM_001164480
NM_001164481
NM_001164482
NM_001164568
NM_011379

RefSeq (protein)

NP_006738
NP_694985

n/a

Location (UCSC) Chr 11: 65.64 – 65.65 Mb Chr 19: 5.65 – 5.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.[3][4]

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N (Mar 1997). "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics. 39 (1): 66–73. doi:10.1006/geno.1996.4464. PMID 9027487. 
  4. ^ a b "Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1". 

Further reading[edit]