SIRPG

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SIRPG
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSIRPG, CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1, signal regulatory protein gamma
External IDsHomoloGene: 56809 GeneCards: SIRPG
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SIRPG
Genomic location for SIRPG
Band20p13Start1,629,152 bp[1]
End1,657,779 bp[1]
RNA expression pattern
PBB GE SIRPG 220485 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039508
NM_018556
NM_080816

n/a

RefSeq (protein)

NP_001034597
NP_061026
NP_543006

n/a

Location (UCSC)Chr 20: 1.63 – 1.66 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[3][4][5] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089012 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750. 
  4. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. 
  5. ^ a b "Entrez Gene: SIRPG signal-regulatory protein gamma". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.