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Signal-regulatory protein gamma
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SIRPG ; CD172g; SIRP-B2; SIRPB2; SIRPgamma; bA77C3.1
External IDs OMIM605466 HomoloGene56809 GeneCards: SIRPG Gene
RNA expression pattern
PBB GE SIRPG 220485 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55423 n/a
Ensembl ENSG00000089012 n/a
UniProt Q9P1W8 n/a
RefSeq (mRNA) NM_001039508 n/a
RefSeq (protein) NP_001034597 n/a
Location (UCSC) Chr 20:
1.63 – 1.66 Mb
PubMed search [1] n/a

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[1][2][3] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[3]


  1. ^ Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750. 
  2. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511. 
  3. ^ a b "Entrez Gene: SIRPG signal-regulatory protein gamma". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.