SIVA1

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SIVA1
Identifiers
Aliases SIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDs MGI: 1353606 HomoloGene: 4692 GeneCards: SIVA1
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIVA1
Genomic location for SIVA1
Band 14q32.33 Start 104,753,100 bp[1]
End 104,768,494 bp[1]
RNA expression pattern
PBB GE SIVA1 210792 x at fs.png

PBB GE SIVA1 203489 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006427
NM_021709

NM_001161737
NM_013929

RefSeq (protein)

NP_006418
NP_068355

NP_001155209
NP_038957

Location (UCSC) Chr 14: 104.75 – 104.77 Mb Chr 14: 112.64 – 112.65 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[5][6]

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[6]

Interactions[edit]

SIVA1 has been shown to interact with CD27.[5]

Siva (protein)[edit]

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [7]

See also[edit]

References[edit]

Further reading[edit]