SIVA1

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SIVA1
Identifiers
AliasesSIVA1, CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor
External IDsMGI: 1353606 HomoloGene: 4692 GeneCards: SIVA1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIVA1
Genomic location for SIVA1
Band14q32.33Start104,753,147 bp[1]
End104,768,494 bp[1]
RNA expression pattern
PBB GE SIVA1 210792 x at fs.png

PBB GE SIVA1 203489 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006427
NM_021709

NM_001161737
NM_013929

RefSeq (protein)

NP_006418
NP_068355

NP_001155209
NP_038957

Location (UCSC)Chr 14: 104.75 – 104.77 MbChr 12: 112.64 – 112.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.[5][6] This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[6]

Interactions[edit]

SIVA1 has been shown to interact with CD27.[5]

Siva (protein)[edit]

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. [7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184990 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064326 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A. 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220.
  6. ^ a b "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor".
  7. ^ Fortin A, MacLaurin JG, Arbour N, et al. (July 2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.

Further reading[edit]