SKAP2

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SKAP2
Protein SKAP2 PDB 1u5e.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2
External IDs MGI: 1889206 HomoloGene: 2919 GeneCards: SKAP2
RNA expression pattern
PBB GE SKAP2 216899 s at fs.png

PBB GE SKAP2 204362 at fs.png

PBB GE SKAP2 204361 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003930
NM_001303468

NM_018773

RefSeq (protein)

NP_001290397
NP_003921

NP_061243.1
NP_061243

Location (UCSC) Chr 7: 26.67 – 27 Mb Chr 6: 51.86 – 52.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.[3][4][5]

Function[edit]

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.[5] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776. 
  4. ^ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. 
  5. ^ a b "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2". 
  6. ^ Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMID 22976304. 

Further reading[edit]