SKIP

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This article is about a human gene. For the kanji indexing system, see Kodansha Kanji Learner's Dictionary. For the non-profit organizations, see SKIP of New York.
INPP5K
Identifiers
Aliases INPP5K, PPS, SKIP, inositol polyphosphate-5-phosphatase K
External IDs MGI: 1194899 HomoloGene: 75059 GeneCards: INPP5K
RNA expression pattern
PBB GE SKIP 202781 s at fs.png

PBB GE SKIP 202782 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135642
NM_016532
NM_130766

NM_008916

RefSeq (protein)

NP_001129114
NP_057616
NP_570122

NP_032942.1
NP_032942

Location (UCSC) Chr 17: 1.49 – 1.52 Mb Chr 11: 75.63 – 75.65 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.[3]

Function[edit]

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[3] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase". 
  4. ^ Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S (Dec 2011). "The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system". Pflügers Archiv. 462 (6): 871–83. doi:10.1007/s00424-011-1028-0. PMID 21938401. 

Further reading[edit]