SL2 may refer to:
- SL2 (group), British DJ and dance rave act
- Leicaflex SL2, a Leica mechanical reflex camera favoured by press photographers
- SL2, dirigeable airship used for bombing Warsaw in WWI
- SL2, car in the Saturn S-Series
- SL2 flavivirus, clones in cancer research
- SL2 RNA, a non-coding RNA involved in trans splicing in lower eukaryotes
- SL postcode area, the Slough postal region covering Farnham
- the mathematical structure SL2 (F), special linear group
- Special linear Lie algebra
- Skylab 2 (SL-2), a NASA space mission
- Situational Leadership II, a leadership theory developed by Paul Hersey
- SL2 (MBTA bus)
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