SLA2

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SLA2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDs MGI: 1925049 HomoloGene: 49989 GeneCards: SLA2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032214
NM_175077

NM_029983

RefSeq (protein)

NP_115590
NP_778252

NP_084259.1
NP_084259

Location (UCSC) Chr 20: 36.61 – 36.65 Mb Chr 2: 156.87 – 156.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[3][4]

Function[edit]

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[4]

Interactions[edit]

SLA2 has been shown to interact with Cbl gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979Freely accessible. PMID 11696592. 
  4. ^ a b "Entrez Gene: SLA2 Src-like-adaptor 2". 
  5. ^ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219. 

Further reading[edit]