SLAMF1

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SLAMF1
PDB 1d4t EBI.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLAMF1, CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1
External IDsOMIM: 603492 MGI: 1351314 HomoloGene: 48162 GeneCards: SLAMF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003037
NM_001330754

NM_013730
NM_001360898

RefSeq (protein)

NP_001317683
NP_003028

NP_038758
NP_001347827

Location (UCSC)Chr 1: 160.61 – 160.65 MbChr 1: 171.59 – 171.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.[5][6] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family. The interaction of SLAMF1 promoter and enhancers with the Early B-cell factor 1 (EBF1) is required for the expression of SLAMF1 gene in B cells. STAT6, IRF4, and NF-kB factors involved in the transfer of the signals from the B-cell receptor, its co-receptors and IL-4R, also play important role in the regulation of SLAMF1 expression.[7]

Interactions[edit]

SLAMF1 has been shown to interact with PTPN11,[8][9] SH2D1A[8][10] and SH2D1B.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117090 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015316 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature. 376 (6537): 260–3. Bibcode:1995Natur.376..260C. doi:10.1038/376260a0. PMID 7617038. S2CID 4319295.
  6. ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".
  7. ^ Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
  8. ^ a b Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood. 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999.
  9. ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
  10. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.

Further reading[edit]

External links[edit]

  • Overview of all the structural information available in the PDB for UniProt: Q13291 (Signaling lymphocytic activation molecule) at the PDBe-KB.