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Signaling lymphocytic activation molecule family member 1
PDB 1d4t EBI.jpg
Rendering of SLAMF1 from PDB 1D4T
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SLAMF1 ; CD150; CDw150; SLAM
External IDs OMIM603492 MGI1351314 HomoloGene48162 GeneCards: SLAMF1 Gene
RNA expression pattern
PBB GE SLAMF1 206181 at tn.png
More reference expression data
Species Human Mouse
Entrez 6504 27218
Ensembl ENSG00000117090 ENSMUSG00000015316
UniProt Q13291 Q9QUM4
RefSeq (mRNA) NM_003037 NM_013730
RefSeq (protein) NP_003028 NP_038758
Location (UCSC) Chr 1:
160.61 – 160.65 Mb
Chr 1:
171.77 – 171.8 Mb
PubMed search [1] [2]

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.[1][2] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family.


SLAMF1 has been shown to interact with PTPN11,[3][4] SH2D1A[3][5] and SH2D1B.[4]


  1. ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature 376 (6537): 260–3. doi:10.1038/376260a0. PMID 7617038. 
  2. ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1". 
  3. ^ a b Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999. 
  4. ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. 
  5. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. 

Further reading[edit]