SLAMF6

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SLAMF6
Protein SLAMF6 PDB 2if7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDs MGI: 1353620 HomoloGene: 49945 GeneCards: SLAMF6
Genetically Related Diseases
toxic diffuse goiter[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052931
NM_001184714
NM_001184715
NM_001184716

NM_030710
NM_001347186
NM_001347187

RefSeq (protein)

NP_001171643
NP_001171644
NP_001171645
NP_443163

NP_109635.1
NP_001334115
NP_001334116
NP_109635

Location (UCSC) Chr 1: 160.49 – 160.52 Mb Chr 1: 171.92 – 171.95 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.[4][5]

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[5]

References[edit]

Further reading[edit]