SLAMF7

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SLAMF7
Identifiers
Aliases SLAMF7, 19A, CD319, CRACC, CS1, SLAM family member 7
External IDs MGI: 1922595 HomoloGene: 49660 GeneCards: SLAMF7
RNA expression pattern
PBB GE SLAMF7 219159 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144539
NM_001347184

RefSeq (protein)

NP_001334113
NP_653122

Location (UCSC) Chr 1: 160.74 – 160.75 Mb Chr 1: 171.63 – 171.65 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.[3][4][5]

The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.[6]

Elotuzumab is an antibody that targets this protein.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion". The Biochemical Journal. 361 (Pt 3): 431–6. PMC 1222324Freely accessible. PMID 11802771. doi:10.1042/0264-6021:3610431. 
  4. ^ Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily". Immunogenetics. 52 (3-4): 302–7. PMID 11220635. doi:10.1007/s002510000274. 
  5. ^ "Entrez Gene: SLAMF7 SLAM family member 7". 
  6. ^ Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B (Feb 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336–40. PMID 24385542. doi:10.1182/blood-2013-09-529800. 

Further reading[edit]