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Aliases SLC11A1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1
External IDs MGI: 1345275 HomoloGene: 73884 GeneCards: SLC11A1
Gene location (Human)
Human chromosome 2
Chr. Chromosome 2 (human)[1]
Human chromosome 2
Genomic location for SLC11A1
Genomic location for SLC11A1
Band No data available Start 218,382,029 bp[1]
End 218,396,894 bp[1]
RNA expression pattern
PBB GE SLC11A1 217473 x at fs.png

PBB GE SLC11A1 210423 s at fs.png

PBB GE SLC11A1 210422 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 218.38 – 218.4 Mb Chr 1: 74.38 – 74.39 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[5][6][7]


This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[8] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000018280 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026177 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (November 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". The Journal of Experimental Medicine. 180 (5): 1741–52. PMC 2191750Freely accessible. PMID 7964458. doi:10.1084/jem.180.5.1741. 
  6. ^ Kishi F (November 1994). "Isolation and characterization of human Nramp cDNA". Biochemical and Biophysical Research Communications. 204 (3): 1074–80. PMID 7980580. doi:10.1006/bbrc.1994.2572. 
  7. ^ a b "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1". 
  8. ^ Teras IuKh, Ryĭgas EM, Kazakova II, Ranne KhP, Trapido LE (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases]". Terapevticheskii Arkhiv. 52 (3): 123–5. PMID 7385031. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.