SLC22A1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
SLC22A1
Identifiers
AliasesSLC22A1, HOCT1, OCT1, oct1_cds, solute carrier family 22 member 1
External IDsOMIM: 602607 MGI: 108111 HomoloGene: 20665 GeneCards: SLC22A1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC22A1
Genomic location for SLC22A1
Band6q25.3Start160,121,815 bp[1]
End160,158,718 bp[1]
RNA expression pattern
PBB GE SLC22A1 207201 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003057
NM_153187

NM_009202

RefSeq (protein)

NP_003048
NP_694857

NP_033228

Location (UCSC)Chr 6: 160.12 – 160.16 MbChr 17: 12.65 – 12.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[5][6]

Function[edit]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]

It is also required for the uptake of metformin by cells.[7][8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175003 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023829 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
  6. ^ a b "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1".
  7. ^ Pryor, R; Cabreiro, F; Haberland, G (16 October 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". Biochemical Journal. 471 (3): 307–322. doi:10.1042/BJ20150497. PMC 4613459. PMID 26475449.
  8. ^ Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.