SLC22A1

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SLC22A1
Identifiers
Aliases SLC22A1, HOCT1, OCT1, oct1_cds, solute carrier family 22 member 1
External IDs MGI: 108111 HomoloGene: 20665 GeneCards: 6580
RNA expression pattern
PBB GE SLC22A1 207201 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003057
NM_153187

NM_009202

RefSeq (protein)

NP_003048.1
NP_694857.1

NP_033228.2

Location (UCSC) Chr 6: 160.12 – 160.16 Mb Chr 17: 12.65 – 12.68 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[2]

See also[edit]

References[edit]

  1. ^ Koehler MR; Wissinger B; Gorboulev V; Koepsell H; Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850. 
  2. ^ a b "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.