SLC22A1

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Solute carrier family 22 (organic cation transporter), member 1
Identifiers
Symbols SLC22A1 ; HOCT1; OCT1; oct1_cds
External IDs OMIM602607 MGI108111 HomoloGene20665 ChEMBL: 5685 GeneCards: SLC22A1 Gene
RNA expression pattern
PBB GE SLC22A1 207201 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6580 20517
Ensembl ENSG00000175003 ENSMUSG00000023829
UniProt O15245 O08966
RefSeq (mRNA) NM_003057 NM_009202
RefSeq (protein) NP_003048 NP_033228
Location (UCSC) Chr 6:
160.54 – 160.58 Mb
Chr 17:
12.65 – 12.68 Mb
PubMed search [1] [2]

Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[2]

See also[edit]

References[edit]

  1. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850. 
  2. ^ a b "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.