SLC22A2

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SLC22A2
Identifiers
AliasesSLC22A2, OCT2, solute carrier family 22 member 2
External IDsMGI: 1335072 HomoloGene: 68293 GeneCards: SLC22A2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC22A2
Genomic location for SLC22A2
Band6q25.3Start160,171,061 bp[1]
End160,277,638 bp[1]
RNA expression pattern
PBB GE SLC22A2 207429 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153191
NM_003058

NM_013667
NM_001355767

RefSeq (protein)

NP_003049

NP_038695
NP_001342696

Location (UCSC)Chr 6: 160.17 – 160.28 MbChr 17: 12.58 – 12.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2[5]) is a protein that in humans is encoded by the SLC22A2 gene.[6][7]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112499 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040966 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ https://www.ncbi.nlm.nih.gov/gene/6582
  6. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
  7. ^ a b "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.