From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases SLC25A10, DIC, solute carrier family 25 member 10
External IDs MGI: 1353497 HomoloGene: 6519 GeneCards: SLC25A10
Genetically Related Diseases
dental caries[1]
RNA expression pattern
PBB GE SLC25A10 218275 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 81.71 – 81.72 Mb Chr 11: 120.49 – 120.5 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Mitochondrial dicarboxylate carrier is a protein that in humans is encoded by the SLC25A10 gene.[4][5][6]


The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM][6]

See also[edit]


  1. ^ "Diseases that are genetically associated with SLC25A10 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE (September 1998). "The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans". The Journal of Biological Chemistry. 273 (38): 24754–9. doi:10.1074/jbc.273.38.24754. PMID 9733776. 
  5. ^ Pannone E, Fiermonte G, Dolce V, Rocchi M, Palmieri F (Mar 1999). "Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3". Cytogenetics and Cell Genetics. 83 (3-4): 238–9. doi:10.1159/000015190. PMID 10072589. 
  6. ^ a b "Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10". 

Further reading[edit]

  • Fiermonte G, Dolce V, Arrigoni R, Runswick MJ, Walker JE, Palmieri F (December 1999). "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family". The Biochemical Journal. 344 Pt 3 (Pt 3): 953–60. doi:10.1042/0264-6021:3440953. PMC 1220721Freely accessible. PMID 10585886. 
  • Douglas MW, Diefenbach RJ, Homa FL, Miranda-Saksena M, Rixon FJ, Vittone V, Byth K, Cunningham AL (July 2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". The Journal of Biological Chemistry. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959. 
  • Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H (September 2005). "Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis". The Journal of Biological Chemistry. 280 (37): 32434–41. doi:10.1074/jbc.M503152200. PMID 16027120. 
  • Khanna H, Hurd TW, Lillo C, Shu X, Parapuram SK, He S, Akimoto M, Wright AF, Margolis B, Williams DS, Swaroop A (September 2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins". The Journal of Biological Chemistry. 280 (39): 33580–7. doi:10.1074/jbc.M505827200. PMC 1249479Freely accessible. PMID 16043481. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.