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Available structures
PDB Ortholog search: PDBe RCSB
Aliases SLC25A12, AGC1, ARALAR, solute carrier family 25 member 12, EIEE39
External IDs MGI: 1926080 HomoloGene: 48235 GeneCards: SLC25A12
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SLC25A12
Genomic location for SLC25A12
Band 2q31.1 Start 171,784,370 bp[1]
End 171,999,859 bp[1]
RNA expression pattern
PBB GE SLC25A12 203340 s at fs.png

PBB GE SLC25A12 203339 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 171.78 – 172 Mb Chr 2: 71.27 – 71.37 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Calcium-binding mitochondrial carrier protein Aralar1 is a protein that in humans is encoded by the SLC25A12 gene.[5][6][7][8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115840 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027010 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ del Arco A, Satrústegui J (September 1998). "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain". The Journal of Biological Chemistry. 273 (36): 23327–34. doi:10.1074/jbc.273.36.23327. PMID 9722566. 
  6. ^ Crackower MA, Sinasac DS, Lee JR, Herbrick JA, Tsui LC, Scherer SW (Apr 2000). "Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24". Cytogenetics and Cell Genetics. 87 (3-4): 197–8. doi:10.1159/000015465. PMID 10702666. 
  7. ^ Palmieri L, Pardo B, Lasorsa FM, del Arco A, Kobayashi K, Iijima M, Runswick MJ, Walker JE, Saheki T, Satrústegui J, Palmieri F (September 2001). "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria". The EMBO Journal. 20 (18): 5060–9. doi:10.1093/emboj/20.18.5060. PMC 125626Freely accessible. PMID 11566871. 
  8. ^ "Entrez Gene: SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12". 

Further reading[edit]

  • Kobayashi K, Sinasac DS, Iijima M, Boright AP, Begum L, Lee JR, Yasuda T, Ikeda S, Hirano R, Terazono H, Crackower MA, Kondo I, Tsui LC, Scherer SW, Saheki T (June 1999). "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein". Nature Genetics. 22 (2): 159–63. doi:10.1038/9667. PMID 10369257. 
  • Sanz R, del Arco A, Ayuso C, Ramos C, Satrústegui J (2000). "Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization". Cytogenetics and Cell Genetics. 89 (3-4): 143–4. doi:10.1159/000015595. PMID 10965105. 
  • Ramoz N, Reichert JG, Smith CJ, Silverman JM, Bespalova IN, Davis KL, Buxbaum JD (April 2004). "Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism". The American Journal of Psychiatry. 161 (4): 662–9. doi:10.1176/appi.ajp.161.4.662. PMID 15056512. 
  • Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P (December 2004). "The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells". The Journal of Biological Chemistry. 279 (53): 55659–66. doi:10.1074/jbc.M409303200. PMID 15494407. 
  • Rabionet R, McCauley JL, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS, Haines JL, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Pericak-Vance MA (May 2006). "Lack of association between autism and SLC25A12". The American Journal of Psychiatry. 163 (5): 929–31. doi:10.1176/appi.ajp.163.5.929. PMID 16648338. 
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 
  • Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ (October 2007). "Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31 (7): 1510–3. doi:10.1016/j.pnpbp.2007.07.010. PMID 17693006. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.