Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21gene.
It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on homozygous mutant mice and ten significant abnormalities were observed, including sub-viability at weaning, decreased body weight, absent pinna reflex, abnormal snout, skull, spine and tooth morphology, atypical indirect calorimetry, body composition and plasma chemistry data, increased mean platelet volume and moderate elevations in auditory thresholds.
Fiermonte, G.; Dolce, V.; Palmieri, L.; Ventura, M.; Runswick, M. J.; Palmieri, F.; Walker, J. E. (2000). "Identification of the Human Mitochondrial Oxodicarboxylate Carrier. BACTERIAL EXPRESSION, RECONSTITUTION, FUNCTIONAL CHARACTERIZATION, TISSUE DISTRIBUTION, AND CHROMOSOMAL LOCATION". Journal of Biological Chemistry276 (11): 8225–8230. doi:10.1074/jbc.M009607200. PMID11083877.
Trynka, G.; Zhernakova, A.; Romanos, J.; Franke, L.; Hunt, K. A.; Turner, G.; Bruinenberg, M.; Heap, G. A.; Platteel, M.; Ryan, A. W.; De Kovel, C.; Holmes, G. K. T.; Howdle, P. D.; Walters, J. R. F.; Sanders, D. S.; Mulder, C. J. J.; Mearin, M. L.; Verbeek, W. H. M.; Trimble, V.; Stevens, F. M.; Kelleher, D.; Barisani, D.; Bardella, M. T.; McManus, R.; Van Heel, D. A.; Wijmenga, C. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF- B signalling". Gut58 (8): 1078–1083. doi:10.1136/gut.2008.169052. PMID19240061.