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Aliases SLC25A37, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217, HT015, solute carrier family 25 member 37
External IDs MGI: 1914962 HomoloGene: 74739 GeneCards: SLC25A37
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 23.53 – 23.58 Mb Chr 14: 69.24 – 69.29 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Mitoferrin-1 is a protein that in humans is encoded by the SLC25A37 gene.[3][4] It is an iron transporter that imports ferrous iron from the intermembrane space of the mitochondria to the mitochondrial matrix for the synthesis of heme groups and Fe-S clusters.[5] It shows homology to mitoferrin-2 (SLC25A28) and is stabilized by ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 10 (Abcb10).[6]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH (Mar 2006). "Mitoferrin is essential for erythroid iron assimilation". Nature. 440 (7080): 96–100. doi:10.1038/nature04512. PMID 16511496. 
  4. ^ "Entrez Gene: SLC25A37 solute carrier family 25, member 37". 
  5. ^ Hentze MW, Muckenthaler MU, Galy B, Camaschella C (Jul 2010). "Two to tango: regulation of Mammalian iron metabolism". Cell. 142 (1): 24–38. doi:10.1016/j.cell.2010.06.028. PMID 20603012. 
  6. ^ Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH (Sep 2009). "Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria". Proceedings of the National Academy of Sciences of the United States of America. 106 (38): 16263–8. doi:10.1073/pnas.0904519106. PMC 2752562Freely accessible. PMID 19805291. 

Further reading[edit]

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (Aug 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901Freely accessible. PMID 10931946. 
  • Li QZ, Eckenrode S, Ruan QG, Wang CY, Shi JD, McIndoe RA, She JX (Nov 2001). "Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age". Mammalian Genome. 12 (11): 830–6. doi:10.1007/s00335001-2075-1. PMID 11845285. 
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.