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Solute carrier family 26 (anion exchanger), member 6
Symbols SLC26A6 ; DKFZp586E1422
External IDs OMIM610068 MGI2159728 HomoloGene99903 IUPHAR: 1101 GeneCards: SLC26A6 Gene
Species Human Mouse
Entrez 65010 171429
Ensembl ENSG00000225697 ENSMUSG00000023259
UniProt Q9BXS9 Q8CIW6
RefSeq (mRNA) NM_001040454 NM_134420
RefSeq (protein) NP_001035544 NP_599252
Location (UCSC) Chr 3:
48.63 – 48.64 Mb
Chr 9:
108.76 – 108.76 Mb
PubMed search [1] [2]

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[1][2][3] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[4]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[3]

See also[edit]


  1. ^ Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667. 
  2. ^ Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665. 
  3. ^ a b "Entrez Gene: SLC26A6 solute carrier family 26, member 6". 
  4. ^ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology: Cell Physiology. 4 288: C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.