SLC27A4

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Solute carrier family 27 (fatty acid transporter), member 4
Identifiers
Symbols SLC27A4 ; ACSVL4; FATP4; IPS
External IDs OMIM604194 MGI1347347 HomoloGene68437 ChEMBL: 4327 GeneCards: SLC27A4 Gene
EC number 6.2.1.-
Orthologs
Species Human Mouse
Entrez 10999 26569
Ensembl ENSG00000167114 ENSMUSG00000059316
UniProt Q6P1M0 Q91VE0
RefSeq (mRNA) NM_005094 NM_011989
RefSeq (protein) NP_005085 NP_036119
Location (UCSC) Chr 9:
128.34 – 128.36 Mb
Chr 2:
29.8 – 29.82 Mb
PubMed search [1] [2]

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.[1][2] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.[3] It is debated whether it is also a fatty acid transporter at the plasma membrane.[4]

See also[edit]

References[edit]

  1. ^ Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta 1443 (3): 381–5. doi:10.1016/s0167-4781(98)00231-0. PMID 9878842. 
  2. ^ "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4". 
  3. ^ Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005). "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry 280 (12): 11948–54. doi:10.1074/jbc.M412629200. PMID 15653672. 
  4. ^ Watkins PA (Jan 2008). "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry 283 (4): 1773–7. doi:10.1074/jbc.R700037200. PMID 18024425. 

Further reading[edit]

  • Hirsch D, Stahl A, Lodish HF (Jul 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America 95 (15): 8625–9. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728. 
  • Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF (Sep 1999). "Identification of the major intestinal fatty acid transport protein". Molecular Cell 4 (3): 299–308. doi:10.1016/S1097-2765(00)80332-9. PMID 10518211. 
  • Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, Fisher RM (Jan 2004). "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome". The Journal of Clinical Endocrinology and Metabolism 89 (1): 392–9. doi:10.1210/jc.2003-030682. PMID 14715877. 
  • Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM (Jun 2004). "Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance". Diabetologia 47 (6): 1118–25. doi:10.1007/s00125-004-1417-4. PMID 15168018. 
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  • Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J (Nov 2006). "Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4". Journal of Cell Science 119 (Pt 22): 4678–88. doi:10.1242/jcs.03280. PMID 17062637.