Plasma membrane monoamine transporter

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SLC29A4
Identifiers
Aliases SLC29A4, ENT4, PMAT, solute carrier family 29 member 4
External IDs MGI: 2385330 HomoloGene: 71345 GeneCards: SLC29A4
Targeted by Drug
cimetidine, desipramine, dipyridamole, fluoxetine, quinidine, quinine, verapamil[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040661
NM_001300847
NM_153247

NM_146257

RefSeq (protein)

NP_001035751
NP_001287776
NP_694979

NP_666369.1
NP_666369

Location (UCSC) Chr 7: 5.27 – 5.31 Mb Chr 5: 142.69 – 142.72 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene.[4] It is known alternatively as the human equilibrative nucleoside transporter-4 (hENT4). Unlike other members of the ENT family, it is impermeable to most nucleosides, with the exception of the inhibitory neurotransmitter and ribonucleoside adenosine, which it is permeable to in a highly pH-dependent manner.

This protein is an integral membrane protein that transports the monoamine neurotransmitters (serotonin, dopamine, norepinephrine) as well as adenosine,[5] from synaptic spaces into presynaptic neurons or neighboring glial cells. It is abundantly expressed in the human brain,[6] heart tissue, and skeletal muscle, as well as in the kidneys. It is relatively insensitive to the high affinity inhibitors (such as SSRIs) of the SLC6A monoamine transporters (SERT, DAT, NET), as well being only weakly sensitive to the adenosine transport inhibitor, dipyridamole. Its transport of monoamines, unlike for adenosine, is pH-insensitive. At low pH, (5.5-6.5 range, as occurs under ischemic conditions) however, its transport efficiency for adenosine becomes greater than for serotonin.

It has 530 amino acid residues with 10–12 transmembrane segments, and is not homologous to other known monoamine transporters, such as the high-affinity SERT, DAT, and NET, or the low-affinity SLC22A OCT family. It was initially identified by a search of the draft human genome database by its sequence homology to ENTs (equilibrative nucleoside transporters).[7]

Ligands[edit]

Inhibitors[edit]

No highly selective PMAT inhibitors are yet available, but a number of existing compounds have been found to act as weak inhibitors of this transporter, with the exception of decynium-22, which is more potent. These compounds include:[8]

Substrates[edit]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier family 29 member 4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (Feb 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Archiv. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422. 
  5. ^ Xia L, Zhou M, Kalhorn TF, Ho HT, Wang J (Jun 2009). "Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity". American Journal of Physiology. Renal Physiology. 296 (6): F1307–13. doi:10.1152/ajprenal.00046.2009. PMC 2692440Freely accessible. PMID 19357181. 
  6. ^ Dahlin A, Xia L, Kong W, Hevner R, Wang J (May 2007). "Expression and immunolocalization of the plasma membrane monoamine transporter in the brain". Neuroscience. 146 (3): 1193–211. doi:10.1016/j.neuroscience.2007.01.072. PMC 2683847Freely accessible. PMID 17408864. 
  7. ^ Engel K, Zhou M, Wang J (Nov 2004). "Identification and characterization of a novel monoamine transporter in the human brain". The Journal of Biological Chemistry. 279 (48): 50042–9. doi:10.1074/jbc.M407913200. PMID 15448143. 
  8. ^ Engel K, Wang J (Nov 2005). "Interaction of organic cations with a newly identified plasma membrane monoamine transporter". Molecular Pharmacology. 68 (5): 1397–407. doi:10.1124/mol.105.016832. PMID 16099839.