SLC2A9

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SLC2A9
Identifiers
Aliases SLC2A9, solute carrier family 2 (facilitated glucose transporter), member 9, GLUT9, GLUTX, UAQTL2, URATv1, solute carrier family 2 member 9
External IDs MGI: 2152844 HomoloGene: 69290 GeneCards: 56606
Genetically Related Diseases
Disease Name References
gout
RNA expression pattern
PBB GE SLC2A9 219991 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001290
NM_020041

NM_001012363
NM_001102414
NM_001102415
NM_145559

RefSeq (protein)

NP_001001290.1
NP_064425.2

n/a

Location (UCSC) Chr 4: 9.77 – 10.05 Mb Chr 5: 38.35 – 38.5 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[1][2][3]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.[4][5][6]

See also[edit]

References[edit]

  1. ^ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667. 
  2. ^ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol 24 (5-6): 455–63. doi:10.1080/09687680701298143. PMID 17710649. 
  3. ^ a b "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9". 
  4. ^ Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics 40 (4): 437–42. doi:10.1038/ng.106. PMID 18327257. 
  5. ^ Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics 40 (4): 430–6. doi:10.1038/ng.107. PMID 18327256. 
  6. ^ Hollingworth P, Sweet R, Sims R, et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry 17: 1316–1327. doi:10.1038/mp.2011.125. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.