SLC30A1

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SLC30A1
Identifiers
Aliases SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDs MGI: 1345281 HomoloGene: 6681 GeneCards: 7779
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021194

NM_009579

RefSeq (protein)

NP_067017.2

NP_033605.1

Location (UCSC) Chr 1: 211.57 – 211.58 Mb Chr 1: 191.91 – 191.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]

Function[edit]

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3]

See also[edit]

References[edit]

  1. ^ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal 14 (4): 639–49. PMC 398127. PMID 7882967. 
  2. ^ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973. 
  3. ^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416. 

Further reading[edit]