SLC31A1

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SLC31A1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SLC31A1, COPT1, CTR1, solute carrier family 31 member 1
External IDs MGI: 1333843 HomoloGene: 1399 GeneCards: 1317
RNA expression pattern
PBB GE SLC31A1 203971 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001859

NM_175090

RefSeq (protein)

NP_001850.1

NP_780299.2

Location (UCSC) Chr 9: 113.22 – 113.26 Mb Chr 4: 62.36 – 62.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

High affinity copper uptake protein 1 (Ctr1) is a protein that in humans is encoded by the SLC31A1 gene.[3][4]

Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A (MIM 300011) and ATP7B (MIM 606882), responsible for the human diseases Menkes syndrome (MIM 309400) and Wilson disease (MIM 277900), respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[supplied by OMIM][4]

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.