Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.    
Function [ edit ]
SLC34A3 contributes to the maintenance of
inorganic phosphate concentration at the kidney. 
Interactions [ edit ]
SLC34A3 has been shown to
interact with PDZK1. 
Clinical Correlation [ edit ]
A mutation in the SLC34A3 gene has been known to cause the
autosomal recessive condition hereditary hypophophatemic rickets with hypercalciuria. This gene is correlated closely with SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase levels of 1,25-dihydroxyvitamin D (yields the hypercalcuria). 
See also [ edit ]
References [ edit ]
Further reading [ edit ]
Forster IC; Hernando N; Biber J; Murer H (2006). "Proximal tubular handling of phosphate: A molecular perspective". Kidney Int. 70 (9): 1548–59. doi: 10.1038/sj.ki.5001813. PMID 16955105.
Yamamoto T, Michigami T, Aranami F, et al. (2007). "Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function". J. Bone Miner. Metab. 25 (6): 407–13. doi: 10.1007/s00774-007-0776-6. PMID 17968493.
Ehnes C, Forster IC, Bacconi A, et al. (2005). "Structure–Function Relations of the First and Fourth Extracellular Linkers of the Type IIa Na+/Pi Cotransporter: II. Substrate Interaction and Voltage Dependency of Two Functionally Important Sites". J. Gen. Physiol. 124 (5): 489–503. doi: 10.1085/jgp.200409061. PMC . 2234003 PMID 15504899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899. PMC . 139241 PMID 12477932.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.