SLC39A1

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SLC39A1
Identifiers
Aliases SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1
RNA expression pattern
PBB GE SLC39A1 217778 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013901

RefSeq (protein)

NP_038929.2
NP_038929

Location (UCSC) Chr 1: 153.96 – 153.97 Mb Chr 3: 90.25 – 90.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[3] [4][5]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[6]


See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721. 
  4. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536. 
  5. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1". 
  6. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516Freely accessible. PMID 16700911. 

Further reading[edit]