Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47, member 1, is a protein that in humans is encoded by the SLC47A1gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.
The multidrug effluxtransporterNorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its homologue from E. coli were identified in 1998, which is the first of Solute carrier family 47 member. NorM seems to function as drug/sodium antiporter which is the first example of Na+-coupled multidrug efflux transporter. NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family. The X-ray structure of the transporter NorM was determined to 3.65 Å, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known multidrug resistance transporter.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Ohta KY, Inoue K, Hayashi Y, Yuasa H (2006). "Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.". Drug Metab. Dispos. 34 (11): 1868–74. doi:10.1124/dmd.106.010876. PMID16928787.
Omote H, Hiasa M, Matsumoto T, et al. (2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.". Trends Pharmacol. Sci. 27 (11): 587–93. doi:10.1016/j.tips.2006.09.001. PMID16996621.
Tsuda M, Terada T, Asaka J, et al. (2007). "Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1.". Am. J. Physiol. Renal Physiol. 292 (2): F593–8. doi:10.1152/ajprenal.00312.2006. PMID17047166.
Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.". J. Pharmacol. Exp. Ther. 322 (2): 695–700. doi:10.1124/jpet.107.123554. PMID17495125.
Tanihara Y, Masuda S, Sato T, et al. (2007). "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.". Biochem. Pharmacol. 74 (2): 359–71. doi:10.1016/j.bcp.2007.04.010. PMID17509534.
Kajiwara M, Terada T, Asaka J, et al. (2007). "Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.". Am. J. Physiol. Renal Physiol. 293 (5): F1564–70. doi:10.1152/ajprenal.00322.2007. PMID17855482.