Sodium-dependent multivitamin transporter

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SLC5A6
Identifiers
AliasesSLC5A6, SMVT, solute carrier family 5 member 6
External IDsMGI: 2660847 HomoloGene: 23277 GeneCards: SLC5A6
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SLC5A6
Genomic location for SLC5A6
Band2p23.3Start27,199,587 bp[1]
End27,212,958 bp[1]
RNA expression pattern
PBB GE SLC5A6 204087 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021095

NM_001177621
NM_001177622
NM_177870
NM_001360022

RefSeq (protein)

NP_066918

NP_001171092
NP_001171093
NP_808538
NP_001346951

Location (UCSC)Chr 2: 27.2 – 27.21 MbChr 5: 31.04 – 31.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[5][6][7]

It is a putative transporter for uptake of biotin and pantothenic acid at the blood-brain barrier.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138074 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006641 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
  6. ^ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
  7. ^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
  8. ^ Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

Further reading[edit]