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SMAC may refer to:
- Sabang Merauke Raya Air Charter, an Indonesian airline
- Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests
- Sid Meier's Alpha Centauri, a computer game
- Southern Maryland Athletic Conference
- Southwestern Michigan Athletic Conference
- Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America
- Supreme Macedonian-Adrianople Committee
- Social Mobile Analytics Cloud
- Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway
- Supramolecular activation cluster, the structure comprising the immunological synapse
| disambiguation page lists articles associated with the title SMAC.
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