SMARCD1

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SMARCD1
Protein SMARCD1 PDB 1uhr.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SMARCD1, BAF60A, CRACD1, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
External IDs MGI: 1933623 HomoloGene: 20670 GeneCards: SMARCD1
RNA expression pattern
PBB GE SMARCD1 209518 at fs.png

PBB GE SMARCD1 203183 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003076
NM_139071

NM_031842

RefSeq (protein)

NP_003067
NP_620710

NP_114030.2
NP_114030

Location (UCSC) Chr 12: 50.08 – 50.1 Mb Chr 15: 99.7 – 99.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.[3][4][5][6]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions[edit]

SMARCD1 has been shown to interact with Glucocorticoid receptor.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307. 
  4. ^ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044. 
  5. ^ a b Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (Aug 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol Cell Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928Freely accessible. PMID 12917342. 
  6. ^ a b "Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1". 

Further reading[edit]