SMARCD3

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SMARCD3
Identifiers
Aliases SMARCD3, BAF60C, CRACD3, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
External IDs MGI: 1914243 HomoloGene: 2314 GeneCards: SMARCD3
RNA expression pattern
PBB GE SMARCD3 204099 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003801
NM_001003802
NM_003078

NM_025891

RefSeq (protein)

NP_001003801
NP_001003802
NP_003069

NP_080167.3
NP_080167

Location (UCSC) Chr 7: 151.24 – 151.28 Mb Chr 5: 24.59 – 24.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene.[5] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (September 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes & Development. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307. 
  4. ^ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (July 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044. 
  5. ^ a b "Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3". 
  6. ^ Puri PL, Mercola M (December 2012). "BAF60 A, B, and Cs of muscle determination and renewal". Genes & Development. 26 (24): 2673–83. doi:10.1101/gad.207415.112. PMC 3533072Freely accessible. PMID 23222103. 

Further reading[edit]