Simple Modular Architecture Research Tool

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Description Identification scheme for protein domains.
Data types captured Protein domains
Organisms all
Research center European Molecular Biology Laboratory
Primary citation PMID 18978020
License Free to academics, but not commercial users
Version 7
Curation policy Yes

Simple Modular Architecture Research Tool (SMART) is a biological database that is used in the identification and analysis of protein domains within protein sequences.[1][2] SMART uses profile-hidden Markov models built from multiple sequence alignments to detect protein domains in protein sequences. The most recent release of SMART contains 1,009 domain models.[3] Data from SMART was used in creating the Conserved Domain Database collection and is also distributed as part of the InterPro database.[4] The database is hosted by the European Molecular Biology Laboratory in Heidelberg.


  1. ^ Schultz J, Milpetz F, Bork P, Ponting CP (May 1998). "SMART, a simple modular architecture research tool: identification of signaling domains". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 5857–64. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884. 
  2. ^ Letunic I, Doerks T, Bork P (January 2009). "SMART 6: recent updates and new developments". Nucleic Acids Res. 37 (Database issue): D229–32. doi:10.1093/nar/gkn808. PMC 2686533. PMID 18978020. 
  3. ^ Letunic I, Doerks T, Bork P (January 2012). "SMART 7: recent updates to the protein domain annotation resource". Nucleic Acids Res. 40 (Database issue): D302–5. doi:10.1093/nar/gkr931. PMC 3245027. PMID 22053084. 
  4. ^ Mulder NJ, Apweiler R, Attwood TK, et al. (September 2002). "InterPro: an integrated documentation resource for protein families, domains and functional sites". Brief. Bioinformatics 3 (3): 225–35. doi:10.1093/bib/3.3.225. PMID 12230031. 

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