SMG5

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SMG5
Protein SMG5 PDB 2hwy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor
External IDs MGI: 2447364 HomoloGene: 9095 GeneCards: 23381
RNA expression pattern
PBB GE SMG5 212147 at tn.png

PBB GE SMG5 34868 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015327
NM_001323614
NM_001323615
NM_001323616
NM_001323617

NM_173188
NM_178246

RefSeq (protein)

NP_056142.2

NP_839977.2

Location (UCSC) Chr 1: 156.25 – 156.28 Mb Chr 3: 88.34 – 88.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[1][2][3] This protein contains a PIN domain that appears to have mutated the residues in the active site.[4]


References[edit]

  1. ^ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. 
  2. ^ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. 
  3. ^ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)". 
  4. ^ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788. 

Further reading[edit]