SMG5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SMG5
Protein SMG5 PDB 2hwy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor
External IDs MGI: 2447364 HomoloGene: 9095 GeneCards: SMG5
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SMG5
Genomic location for SMG5
Band 1q22 Start 156,249,224 bp[1]
End 156,282,825 bp[1]
RNA expression pattern
PBB GE SMG5 212147 at fs.png

PBB GE SMG5 34868 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015327
NM_001323614
NM_001323615
NM_001323616
NM_001323617

NM_173188
NM_178246

RefSeq (protein)

NP_001310543
NP_001310544
NP_001310545
NP_001310546
NP_056142

NP_839977

Location (UCSC) Chr 1: 156.25 – 156.28 Mb Chr 1: 88.34 – 88.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[5][6][7] This protein contains a PIN domain that appears to have mutated the residues in the active site.[8]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198952 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001415 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. 
  6. ^ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. 
  7. ^ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)". 
  8. ^ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413Freely accessible. PMID 17053788. 

Further reading[edit]