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SMG5 nonsense mediated mRNA decay factor
Protein SMG5 PDB 2hwy.png
PDB rendering based on 2hwy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SMG5 ; EST1B; LPTS-RP1; LPTSRP1; SMG-5
External IDs OMIM610962 MGI2447364 HomoloGene9095 GeneCards: SMG5 Gene
RNA expression pattern
PBB GE SMG5 212147 at tn.png
PBB GE SMG5 34868 at tn.png
More reference expression data
Species Human Mouse
Entrez 23381 229512
Ensembl ENSG00000198952 ENSMUSG00000001415
UniProt Q9UPR3 Q6ZPY2
RefSeq (mRNA) NM_015327 NM_173188
RefSeq (protein) NP_056142 NP_839977
Location (UCSC) Chr 1:
156.25 – 156.28 Mb
Chr 3:
88.34 – 88.36 Mb
PubMed search [1] [2]

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[1][2][3] This protein contains a PIN domain that appears to have mutated the residues in the active site.[4]


  1. ^ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. 
  2. ^ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. 
  3. ^ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)". 
  4. ^ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788. 

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