SMG5

SMG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HWY
Identifiers
Aliases	SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962; MGI: 2447364; HomoloGene: 9095; GeneCards: SMG5; OMA:SMG5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,282,825 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,269,645 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; anterior pituitary; ; right adrenal gland; ; granulocyte; ; right hemisphere of cerebellum; ; C1 segment; ; right adrenal cortex; ; left adrenal cortex; ; skin of leg;
	Top expressed in
	spermatocyte; ; spermatid; ; superior frontal gyrus; ; neural layer of retina; ; ventricular zone; ; lip; ; muscle of thigh; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; histone deacetylase binding; protein binding; telomeric DNA binding; ubiquitin protein ligase binding; ribonuclease activity; ribonucleoprotein complex binding; telomerase RNA binding;
Cellular component	cytoplasm; cytosol; nucleus; telomerase holoenzyme complex;
Biological process	regulation of dephosphorylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; regulation of telomere maintenance; regulation of telomere maintenance via telomerase; regulation of RNA stability; RNA phosphodiester bond hydrolysis; telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	23381
	229512
	ENSG00000198952
	ENSMUSG00000001415
	Q9UPR3
	Q6ZPY2
	NM_015327; NM_001323614; NM_001323615; NM_001323616; NM_001323617
	NM_173188; NM_178246
	NP_001310543; NP_001310544; NP_001310545; NP_001310546; NP_056142
	NP_839977
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.^[5]^[6]^[7] This protein contains a PIN domain that appears to have mutated the residues in the active site.^[8]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198952 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001415 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087.
^ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629.
^ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
^ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788.

References

Further reading