SNAP-94847

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SNAP-94847
SNAP-94847 structure.png
Identifiers
ChemSpider
Chemical and physical data
Formula C29H32F2N2O2
Molar mass 478.572
3D model (Jmol)
  (verify)

SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects,[1][2] and also reduces food consumption suggesting a possible anorectic effect.[3]

References[edit]

  1. ^ David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (April 2007). "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics. 321 (1): 237–48. doi:10.1124/jpet.106.109678. PMID 17237257. 
  2. ^ Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA (February 2009). "The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents". Behavioural Brain Research. 197 (2): 284–91. doi:10.1016/j.bbr.2008.08.026. PMID 18793675. 
  3. ^ Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y (July 2009). "Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats". Psychopharmacology. 205 (1): 129–40. doi:10.1007/s00213-009-1523-6. PMC 3143407Freely accessible. PMID 19340414.