|Description||a wiki of human single-nucleotide polymorphisms and genotypes|
|single-nucleotide polymorphisms, genotypes, genes, variation|
|Primary citation||PMID 22140107|
|Web service URL||bots|
|License||Creative Commons Attribution-Noncommercial-Share Alike 3.0 United States License|
SNPedia (pronounced "snipedia") is a wiki-based bioinformatics web site that serves as a database of single nucleotide polymorphisms (SNPs). Each article on a SNP provides a short description, links to scientific articles and personal genomics web sites, as well as microarray information about that SNP. Thus SNPedia may support the interpretation of results of personal genotyping from, e.g., 23andMe and similar companies.
An associated computer program called Promethease, also developed by the SNPedia team, allows users to compare personal genetics results against the SNPedia database, generating a report with information about a person's attributes, such as propensity to diseases, based on the presence of specific SNPs within their genome.
In May 2008 Cariaso, using Promethease, won an online contest sponsored by 23andMe to determine as much information as possible about an anonymous woman based only on her genome. Cariaso won in all three categories of "accuracy, creativity and cleverness". In 2009, the anonymous woman ("Lilly Mendel") was revealed to be 23andMe co-founder Linda Avey, allowing a direct comparison between her actual traits and those predicted by Promethease a year earlier.
In a June 2008 article on personal genomics, a doctor from the Southern Illinois University School of Medicine said:
|“||The availability of online tools such as SNPedia means we are now in the position where the patient often knows more about their risk implications than their doctor [...]||”|
|“||We are fast approaching an era in which genetic information is no longer exclusive or medicalized. Instead, as screening costs plummet and our knowledge about genetics expands, virtually everyone will soon be able to have their genotypes at their fingertips. Knowing and sharing that information will enhance, not jeopardize, our sense of ourselves, change the way we consume medicine and plan for the future, and influence how we relate to each other.||”|
Members of the medical community have criticised Promethease for technical complexity and a poorly defined "magnitude" scale that causes misconceptions, confusion and panic among its users..
- Michael Cariaso (2007-12-17). "SNPedia: A Wiki for Personal Genomics". Bio-IT World.
- John Carey (2008-10-23). "Is Genetic Testing Really Good for Your Health?". LEX18.[permanent dead link]
- Daniel MacArthur (2008-11-05). "Nature special issue on personal genomics". scienceblogs.com. Archived from the original on 2008-11-09. Retrieved 2008-11-06.
- "Genes R Us" (PDF). Science. 319 (5860): 139. 11 January 2008. doi:10.1126/science.319.5860.139b.
- "Category:Is a medical condition - SNPedia". www.snpedia.com. Retrieved 2019-06-27.
- SNPedia: a wiki supporting personal genome annotation, interpretation and analysis, Michael Cariaso and Greg Lennon, Nucleic Acids Research, 2011, 1–5
- And the Winner Is..., Matthew Crenson, The Spittoon, May 14, 2008
- "SNPedia:User:Lilly Mendel".
- Lisa Nainggolan (2008-06-23). "Letting the genome out of the bottle: Unraveling the genetics of heart disease". theheart.org by WebMD.
- Ronald Bailey (January 2011). "I'll Show You My Genome. Will You Show Me Yours?". Reason.
- Official website
- Michael Cariaso - Next-Gen Sequencing, Wikis and SNPedia, Webcast from Bio-ITWorld.com.
- Promethease on SNPedia