SNRPB

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SNRPB
Protein SNRPB PDB 1d3b.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
External IDs MGI: 98342 HomoloGene: 134543 GeneCards: SNRPB
RNA expression pattern
PBB GE SNRPB 208821 at fs.png

PBB GE SNRPB 213175 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198216
NM_003091

NM_009225

RefSeq (protein)

NP_003082
NP_937859

NP_033251.1
NP_033251

Location (UCSC) Chr 20: 2.46 – 2.47 Mb Chr 2: 130.17 – 130.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.[3][4]

Function[edit]

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.[4]

Interactions[edit]

SNRPB has been shown to interact with DDX20[5] and Coilin.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. doi:10.1016/0378-1119(92)90574-9. PMID 1376292. 
  4. ^ a b "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1". 
  5. ^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095Freely accessible. PMID 10601333. 
  6. ^ Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMC 312817Freely accessible. PMID 11641277. 

Further reading[edit]