SNX1

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SNX1
PDB 2i4k EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNX1, HsT17379, VPS5, sorting nexin 1
External IDs OMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SNX1
Genomic location for SNX1
Band 15q22.31 Start 64,094,123 bp[1]
End 64,146,090 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242933
NM_003099
NM_148955
NM_152826

NM_019727

RefSeq (protein)

NP_001229862
NP_003090
NP_683758

NP_062701

Location (UCSC) Chr 15: 64.09 – 64.15 Mb Chr 9: 66.09 – 66.13 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[5] SNX1 is a component of the retromer complex.[6][7]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000028528 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032382 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. doi:10.1126/science.272.5264.1008. PMID 8638121. 
  6. ^ Vergés M (2008). "Retromer: multipurpose sorting and specialization in polarized transport". Int Rev Cell Mol Biol. 271: 153–98. doi:10.1016/S1937-6448(08)01204-5. PMID 19081543. 
  7. ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274Freely accessible. PMID 18472259. 
  8. ^ "Entrez Gene: sorting nexin 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.