SNX13

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SNX13
Identifiers
Aliases SNX13, RGS-PX1, sorting nexin 13
External IDs MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13
RNA expression pattern
PBB GE SNX13 215366 at fs.png

PBB GE SNX13 213292 s at fs.png

PBB GE SNX13 215820 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015132

NM_001014973

RefSeq (protein)

NP_055947

NP_001014973.2
NP_001014973

Location (UCSC) Chr 7: 17.79 – 17.94 Mb Chr 12: 35.05 – 35.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[3][4][5]

Function[edit]

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026Freely accessible. PMID 11485546. 
  4. ^ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (November 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science. 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322. 
  5. ^ a b "Entrez Gene: SNX13 sorting nexin 13". 

Further reading[edit]

  • Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. 
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  • Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region". Cytogenetic and Genome Research. 97 (3-4): 167–70. doi:10.1159/000066618. PMID 12438708. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752Freely accessible. PMID 14759258.