SNX2

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Sorting nexin 2
Identifiers
Symbols SNX2 ; TRG-9
External IDs OMIM605929 MGI1915054 HomoloGene2332 GeneCards: SNX2 Gene
RNA expression pattern
PBB GE SNX2 202114 at tn.png
PBB GE SNX2 202113 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6643 67804
Ensembl ENSG00000205302 ENSMUSG00000034484
UniProt O60749 Q9CWK8
RefSeq (mRNA) NM_001278199 NM_026386
RefSeq (protein) NP_001265128 NP_080662
Location (UCSC) Chr 5:
122.77 – 122.83 Mb
Chr 18:
53.18 – 53.22 Mb
PubMed search [1] [2]

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[1][2]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[2]

Interactions[edit]

SNX2 has been shown to interact with FNBP1.[3][4]

References[edit]

  1. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology 18 (12): 7278–87. PMC 109309. PMID 9819414. 
  2. ^ a b "Entrez Gene: SNX2 sorting nexin 2". 
  3. ^ Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters 554 (1-2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906. 
  4. ^ Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682. 

Further reading[edit]