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Sorting nexin 2
Symbols SNX2 ; TRG-9
External IDs OMIM605929 MGI1915054 HomoloGene2332 GeneCards: SNX2 Gene
RNA expression pattern
PBB GE SNX2 202114 at tn.png
PBB GE SNX2 202113 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6643 67804
Ensembl ENSG00000205302 ENSMUSG00000034484
UniProt O60749 Q9CWK8
RefSeq (mRNA) NM_001278199 NM_026386
RefSeq (protein) NP_001265128 NP_080662
Location (UCSC) Chr 5:
122.11 – 122.17 Mb
Chr 18:
53.18 – 53.22 Mb
PubMed search [1] [2]

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[1][2]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[2]


SNX2 has been shown to interact with FNBP1.[3][4]


  1. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414. 
  2. ^ a b "Entrez Gene: SNX2 sorting nexin 2". 
  3. ^ Fuchs, U; Rehkamp G F; Slany R; Follo M; Borkhardt A (November 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. (Netherlands) 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. ISSN 0014-5793. PMID 14596906. 
  4. ^ Fuchs, U; Rehkamp G, Haas O A, Slany R, Kōnig M, Bojesen S, Bohle R M, Damm-Welk C, Ludwig W D, Harbott J, Borkhardt A (July 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (15): 8756–61. doi:10.1073/pnas.121433898. ISSN 0027-8424. PMC 37508. PMID 11438682. 

Further reading[edit]