SNX2

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SNX2
Identifiers
AliasesSNX2, TRG-9, sorting nexin 2
External IDsMGI: 1915054 HomoloGene: 2332 GeneCards: SNX2
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SNX2
Genomic location for SNX2
Band5q23.2Start122,774,996 bp[1]
End122,830,108 bp[1]
RNA expression pattern
PBB GE SNX2 202113 s at fs.png

PBB GE SNX2 202114 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003100
NM_001278199

NM_026386
NM_001357463

RefSeq (protein)

NP_001265128
NP_003091

NP_080662
NP_001344392

Location (UCSC)Chr 5: 122.77 – 122.83 MbChr 18: 53.18 – 53.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[5][6]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[6]

Interactions[edit]

SNX2 has been shown to interact with FNBP1.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205302 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034484 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309Freely accessible. PMID 9819414. 
  6. ^ a b "Entrez Gene: SNX2 sorting nexin 2". 
  7. ^ Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1-2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906. 
  8. ^ Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508Freely accessible. PMID 11438682. 

Further reading[edit]