Sorting nexin family member 27, also known as SNX27, is a humangene.
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID12461558.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID9455484.
Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID15466885.
Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID17351151.
MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID17577583.