SNX4

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SNX4
Identifiers
Aliases SNX4, ATG24B, sorting nexin 4
External IDs MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4
RNA expression pattern
PBB GE SNX4 212652 s at fs.png

PBB GE SNX4 205329 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003794

NM_080557

RefSeq (protein)

NP_003785

NP_542124.1
NP_542124

Location (UCSC) Chr 3: 125.45 – 125.52 Mb Chr 16: 33.25 – 33.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[3][4]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[4]

Interactions[edit]

SNX4 has been shown to interact with BIN1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309Freely accessible. PMID 9819414. 
  4. ^ a b "Entrez Gene: SNX4 sorting nexin 4". 
  5. ^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell. Sci. England. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730. 

Further reading[edit]